Sherlock Holmes is awakened in modern times from suspended animation as a result of an earthquake. He is aided in his recovery by Dr. Amy Winslow (Debrah Farentino), who lives in Baker Street in San Francisco. Holmes pits his wits against the descendants of the Moriarty family, led by James Moriarty Booth. He is also aided by a new group of Baker Street Irregulars led by Zapper (Mark Adair-Rios).