John Murdoch awakens in a hotel bathtub, suffering from amnesia. He receives a phone call from Dr. Daniel Schreber, who urges him to flee the hotel to evade a group of men who are after him. In the room, Murdoch discovers the corpse of a ritualistically murdered woman along with a bloody knife. He flees the scene, just as the group of pale men in trenchcoats (later identified as "the Strangers") arrive.