Luella Delano (Cathy Moriarty), a witness against the American Mafia is being secretly held until the trial when a violent attempt against her kills several of her guards, as well as her husband. She disappears and Chris Lecce (Dreyfuss) and Bill Reimers (Estevez) are called upon due to their excellent surveillance record, to stake out a lakeside home where she is believed to be. Unlike their earlier Stakeout (1987 film), this time they are accompanied by Gina Garrett (O'Donnell) from the DA's office and her pet rottweiler 'Archie', covered as husband, wife and son.