In the "cartoon dimension" mad scientist Doctor Carnage experiments on a man, then disembowels him and rips his skull out through his stomach. On Earth, sisters Cindy and Candy are left alone with Cindy's friend Amy. While Cindy and Amy call over Rick and Eddie, Candy watches a ''Terror Toons'' DVD that she received in the mail. Created by Satan, the DVD depicts the antics of Doctor Carnage and his accomplice Max Assassin, a stolen lab monkey that was mutated into a monster by Carnage.