Manhattanite Julie Messinger, a complacent housewife and mother of two raucous young sons, is married to Richard, a chauvinistic and self-centered magazine art director and author of a best-selling children's book. When he falls into a coma during minor surgery to remove a nonmalignant mole on his neck, Julie learns from his doctor, Dr. Timmy Spector, that another surgeon nicked his artery, necessitating a blood transfusion to which he had a rare allergic reaction. The following day, Julie is told Richard has overcome the reaction, but his liver has sustained serious damage requiring immediate treatment. In quick succession, all his organs begin to fail.