Paul Matthews (Tate Donovan) is a lonely biochemist with a crush on his unavailable co-worker, biologist Diane Farrow (Sandra Bullock). His friends take him to a gypsy on 34th and Vine named Madame Ruth (Anne Bancroft). After reading his palm and seeing absolutely no romance in his life, Ruth gives him a small amount of Love Potion No. 8 on a piece of paper. As a scientist, Paul has doubts and ends up throwing it in the trash when he gets home. Around this time, Paul's friends buy him the services of Marisa, but all they do is talk.