A story of relationships, ''Happy. Thank You. More. Please.'' deals with the struggles facing several pairs trying to find their way. The film centers on Sam (Radnor), a writer, and Rasheen (Algieri), a foster care child, who meet each other when Rasheen is abandoned on the subway. The film comes to also involve Sam's best friend Annie (Åkerman), a woman with alopecia trying to find a reason to be loved; his cousin Mary Catherine (Kazan) and her boyfriend Charlie (Schreiber), a couple facing the prospect of leaving New York; and Mississippi (Mara), a waitress/singer trying to make it in the city.