In the 19th century, a young boy named Charles watches as his family is slaughtered by a werewolf. Before dying, Charles' mother gives him a silver amulet of a howling wolf head, which belonged to his grandfather, who was a "Great Hunter" of werewolves. Charles escapes death by activating a trap which causes a chandelier to fall and kill the attacking werewolf. Twenty-five years later, Charles is a werewolf bounty hunter, working alongside a band of other hunters to rid the world of all werewolves. Werewolves in this fictional world can inflict lycanthropy. Infected individuals are typically shot in the head, after which their bodies are burned. Werewolves are usually only able to transform during the full moon. Charles and company receive an offer to hunt down a particularly vicious werewolf of a new breed. This new type of werewolf is able to transform three nights in a row.