Georgia O'Keeffe is a young painter in the 1910s, while Alfred Stieglitz is New York-based photographer and art impresario, who discovers her works. Later, when O'Keeffe discovers that her works are displayed at an art gallery without her permission, she confronts Stieglitz. However, he manages to charm her, and starts their 20-year relationship. Stieglitz, 23 years senior to O'Keeffe, subsequently starts living with her and later divorces his wife to marry her. However, over the years, as O'Keeffe becomes a famous artist, their relationship deteriorates.